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. 2018 Mar 23;4(1):00130-2017. doi: 10.1183/23120541.00130-2017

FIGURE 3.

FIGURE 3

Effects of a caspase-1 inhibitor and NLRP3 inhibitor on nontypeable Haemophilus influenzae (NTHi)-induced interleukin (IL)-1β production. a) Peripheral blood mononuclear cells (PBMCs) and bronchoalveolar lavage (BAL) cells were cultured ex vivo for 24 h with NTHi in the presence or absence of the caspase-1 inhibitor (C1I) Z-YVAD-FMK. IL-1β produced by healthy control (HC) PBMCs (n=20), protracted bacterial bronchitis (PBB) PBMCs (n=20), BAL macrophages (PBB BAL Mac) (n=9) and BAL neutrophils (PBB BAL Neut) (n=9). b) BAL macrophages (n=9) were cultured ex vivo for 24 h in the presence of NTHi and NLRP3 inhibitor MCC950. Data are presented as mean±sd. *: p<0.05; **: p<0.01; ***: p<0.001 by Wilcoxon matched-pairs signed rank test.