Table 4.
Apixaban pharmacokinetics depending on CYP3A5 (rs776746) genotypes
| Parameters | Genotypes
|
p-value | |
|---|---|---|---|
| GG (n=14) | AG (n=3) | ||
| Cmax (ng/mL), geometric mean (CV%) | 116.5 (53) | 170.0 (22) | 0.362 |
| AUC(0, τ) (ng·h/mL), geometric mean (CV%) | 940.1 (54) | 1395.9 (21) | 0.509 |
| AUC(0, ∞) (ng·h/mL), geometric mean (CV%) | 2745.8 (86) | 2775.3 (17) | 0.840 |
| Tmax (hours), median (min; max) | 3.5 (1; 4) | 2 (1; 3) | 0.156 |
| t1/2 (hours), mean (SD) | 18.4 (15) | 11.1 (2.5) | 0.633 |
Notes: Cmax, maximum plasma concentration; AUC(0, τ), area under the curve “concentration–time” to the last measurement; AUC(0, ∞), area under the curve “concentration–time” to infinity; Tmax, time to maximum plasma concentration; t1/2, half-life.
Abbreviations: CV%, coefficient of variation; min, minimum; max, maximum; SD, standard deviation.