Figure 1.

Sevoflurane post-conditioning reduced brain edema and improved neurological function following a TBI.

Notes: (A) There were no differences between the pre-operative and post-operative scores in the sham group. Sevoflurane post-conditioning (TBI+Sevo group) obtained a lower mNSS beginning at day 3 post-injury than the TBI group (P < 0.05). (B) Brain water content increased more in the TBI rats then in the sham controls and reached a peak on day 3 post-injury (P < 0.05). Rats subjected to sevoflurane post-conditioning had less brain water content on day 3 than the rats in the TBI group (P < 0.05). Data are represented as mean ± SEM (n = 6). *P < 0.05 vs TBI group.

Abbreviations: mNSS, Modified Neurological Severity Score; SEM, standard error of the mean; Sevo, Sevoflurane; TBI, traumatic brain injury.