Figure 6.

Sevoflurane post-conditioning suppressed the expression of pro-apoptotic proteins following the TBI.

Notes: (A) Protein expression of the cleaved caspase-3 and the Bax were downregulated, although the Bcl-2 expression was upregulated by the sevoflurane treatment on day 3 following the TBI. 3-MA treatment abolished the anti-apoptotic effect of the sevoflurane post-conditioning. Representative Western blot displays caspase-3, Bax, and Bcl-2 levels. (B) Relative expression levels of the apoptotic factors. Data are represented as mean ± SEM (n = 6). *P < 0.05 vs TBI group; ^#P < 0.05 vs TBI+Sevo group.

Abbreviations: SEM, standard error of the mean; Sevo, Sevoflurane; TBI, traumatic brain injury; 3-MA, 3-methyladenine.