Table 1.
Patients’ baseline characteristics (safety population)
| Variables | Values |
|---|---|
| N | 27 |
| Age (years) | |
| Mean (SD) | 62.7 (8.6) |
| Median (range) | 62 (48–81) |
| Sex, n (%) | |
| Male | 21 (78) |
| Female | 6 (22) |
| Race, n (%) | |
| Caucasian | 24 (89) |
| Asian | 3 (11) |
| Weight (kg) | |
| Mean (SD) | 84.5 (14.8) |
| Median (range) | 85 (51–120) |
| Age at PD onset (years) | |
| Mean (SD) | 52.3 (8.7) |
| Median (range) | 50 (36–74) |
| “Off” time (h/day) | |
| Mean (SD) | 5.9 (2.2) |
| Median (range) | 5.7 (2.0–11.0) |
| Hoehn & Yahr stage,a n (%) | |
| 2 | 13 (48) |
| 3 | 10 (37) |
| 4 | 4 (15) |
| Levodopa IR dosage (mg/day) | |
| Mean (SD) | 815.7 (249.7) |
| Median (range) | 800 (500–1,250) |
| Levodopa IR dosing frequency (doses/day) | |
| Mean (SD) | 5.4 (1.6) |
| Median (range) | 5 (4–10) |
| Finger-tapping score (taps/min) | |
| “On” state | |
| Mean (SD) | 170.4 (64.6) |
| Median (range) | 163 (73–327) |
| “Off” state | |
| Mean (SD) | 117.9 (44.1) |
| Median (range) | 116 (44–229) |
| UPDRS Part III score | |
| “On” state | |
| Mean (SD) | 17.6 (8.5) |
| Median (range) | 17 (1–32) |
| “Off” state | |
| Mean (SD) | 35.9 (9.4) |
| Median (range) | 36 (20–51) |
Note:
a
During “on” time.
Abbreviations: IR, immediate release; PD, Parkinson’s disease; SD, standard deviation; UPDRS, Unified Parkinson’s Disease Rating Scale.