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. 2018 Mar 22;13:1819–1829. doi: 10.2147/IJN.S152976

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(A) Structure of bCD-PLL and (B) a diagram of the experimental protocol for tracking EPCs. (C) Example of ROIs in MRI. T₂-weighted images were used for selecting ROIs to measure the T₁ relaxation time, noting the ROIs selected from the ischemic muscle. (D) Example of ROIs in optical imaging. The average optical signals of ischemic muscle and signal ratio (labeled EPCs/saline =2/1) were calculated from ROI analyses in two groups.

Abbreviations: bCD, bacterial cytosine deaminase; PLL, poly-L-lysine; EPC, endothelial progenitor cell; ROI, region of interest; MRI, magnetic resonance imaging; DOTA, tetraazacyclododecane-1,4,7,10-tetraacetic acid; ICP-MS, inductively coupled plasma mass spectrometry.