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. 2018 Mar 22;13:1819–1829. doi: 10.2147/IJN.S152976

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© 2018 Peng et al. This work is published and licensed by Dove Medical Press Limited

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bCD-PLL-labeled EPCs observed in ischemic muscle using NIR optical imaging (A and B) in vivo (left-lateral and prone position) and (C) in vitro. Representative images showing that the signals observed in the ischemic hindlimbs on days 1, 3, 5, 7 and 10 after injection of bCD-PLL-labeled EPCs were significantly stronger than in the control group. (D) The average signal levels in ischemic muscle and (E) the signal ratio (labeled EPCs/saline) were calculated from ROI analyses of the two groups. **P<0.01, ***P<0.001.

Abbreviations: bCD, bacterial cytosine deaminase; PLL, poly-L-lysine; EPC, endothelial progenitor cell; NIR, near infrared; ROI, region of interest; Fluo, fluorescence; C.C. fluo, color-coded fluorescence.