Table 8. Activation differences between adolescent AN and control participants for emotional stimuli.
Stimulus Category | Brain region | H | Talairach coordinates | BA | Significance | ||
---|---|---|---|---|---|---|---|
x | y | z | |||||
negative | |||||||
CON>AN | |||||||
Cerebellum | R | 7 | -66 | -4 | - | 𝑡 = -6.64, p≤.0001*** | |
Anterior Cingulate | R | 6 | 16 | 40 | 32 | 𝑡 = -3.80, p = .0001** | |
Striatum | L | -11 | 1 | 12 | - | 𝑡 = -4.07, p≤.0001** | |
Striatum | R | 6 | 6 | 8 | - | 𝑡 = -4.28, p≤.0001** | |
Inferior frontal gyrus | R | 41 | 33 | -7 | 47 | 𝑡 = -3.29, p = .0010* | |
neutral | |||||||
AN> CON | |||||||
Medial prefrontal gyrus | R | 23 | 41 | -15 | 11 | 𝑡 = 3.90, p≤.0001** | |
CON>AN | |||||||
Cerebellum | R | 7 | -66 | -4 | - | 𝑡 = -4.74, p≤.0001*** | |
positive | |||||||
AN>CON | |||||||
Medial prefrontal gyrus | R | 23 | 41 | -15 | 11 | 𝑡 = 3.79, p = .0002** | |
CON>AN | |||||||
Cerebellum | R |
23 7 |
-68 -66 |
-24 -4 |
- - |
𝑡𝑡 = -3.19, p = .0014* 𝑡 = -5.25, p≤.0001*** |
|
Striatum | L | -11 | 1 | 12 | - | 𝑡 = -4.07, p = .0004* | |
Striatum | R | 6 25 |
6 5 |
8 5 |
- - |
𝑡 = -4.28, p≤.0001*** 𝑡 = -3.21, p = .0013* |
|
Anterior cingulate | R | 4 | 23 | 38 | 32 | 𝑡 = -3.47, p = .0005* | |
Precuneus | L | -20 | -65 | 40 | 7 | 𝑡 = -3.57, p = .0003** | |
Inferior frontal gyrus | R | 41 | 33 | -7 | 47 | 𝑡 = -4.33 p≤.0001*** | |
Inferior frontal gyrus | L | -41 | 33 | -7 | 47 | 𝑡 = -3.99, p≤.0001** | |
Hippocampus | R | 27 | -17 | -16 | - | 𝑡 = -4.26 p≤.0001*** |
BA = Brodman Area, H = Hemisphere. T score and p value (* = < .05, ** = < .01, *** = < .001 after Bonferroni correction) are provided.