FIGURE 1. A).

An average improvement of Melasma Area and Severity Index (mMASI) score was achieved by the Polypodium leucotomos extract (PLE) and placebo groups at each visit as compared with the score at baseline. B) The average MASI scores achieved by the PLE and placebo groups at each visit. Statistical significances as compared with at baseline are shown as **p≤0.01; ***p≤0.001. Statistical significances between both groups for each time visit are shown as #p≤0.05.