Table 4. Extraction recovery and matrix effect of BBR, SIM and SHA (n = 6) and d6-BBR, d6-SIM and d6-SHA (n = 6x3).

Sample	Concentration (ng/mL)	Recovery (%) +/- SEM	Matrix Effect (%) +/- SEM
Berberine	1.4	88.1 +/- 2.3	96.9 +/- 1.5
	5	87.0 +/- 3.9	89.6 +/- 2.8
	25	90.8 +/- 0.9	102.2 +/- 1.2
D6-berberine	31.2	88.2 +/- 2.7	101.0 +/- 2.3
Simvastatin	1.4	99.6 +/ - 2.8	85.3 +/- 7.7
	25	105.8 +/- 1.1	84.5 +/- 2.0
	125	84.6 +/- 6.5	109.2 +/- 8.6
D6-simvastatin	156.25	101.9 +/- 3.2	86.9 +/- 4.0
Simvastatin hydroxy acid	1.4	96.2 +/- 2.9	41.8 +/- 2.8
	25	99.7 +/- 3.0	32.7 +/-0.5
	125	103.6 +/- 6.4	30.3 +/- 1.7
D6-simvastatin hydroxy acid	156.25	93.6 +/- 2.6	31.2 +/- 1.0