Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
LD50 (mg/kg) values of the six kavalactone components in Kava
| Species | Kawain | Dihydro- kawain |
Methysticin | Dihydromethysticin | Yangonin | Demethoxy- Yangonin |
|---|---|---|---|---|---|---|
| Mouse | ||||||
| oral | 1130 | 920 | — | 1050 | >1500 | >800 |
| ip | 420 | 325 | 530 | 420 | >1500 | >800 |
| iv | 69 | 53 | 49 | — | 41 | 55 |
| Dog | ||||||
| ip | — | >200 | — | >200 | — | — |
| Cat | ||||||
| ip | — | >250 | — | — | — | — |
| Rabbit | ||||||
| ip | — | >350 | — | 300 | — | — |
