Figure 6.

Fitted longitudinal forced expiratory volume (FEV₁) (left) and pulmonary exacerbation event (right) data over age for representative cystic fibrosis patients using the joint hierarchical Gaussian process model. Each dot in the left panel represents observed FEV₁ for a patient at a given age, while each dot in the right panel indicates whether or not a given patient has experienced a pulmonary exacerbation. The smooth red line in each graph is the estimate of age-related progression at the population level. The individual blue lines are the fitted profiles representing personalized predictions based on the joint hierarchical Gaussian process.