Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Mar 1;145(5):dev159467. doi: 10.1242/dev.159467

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

PMC Copyright notice

Fig. 6. — Canonical Hippo signalling is necessary and sufficient to control the nuclear localisation of Yki:GFP in follicle cells, whereas a Src family kinase inhibitor has no effect. (A) Endogenously tagged Yki:GFP localises to the nucleus in stretch cells and to the cytoplasm in columnar cells. (B) Overexpression of Hippo kinase (Hpo) with GR1.Gal4 in follicle cells causes Yki:GFP to relocalise to the cytoplasm in all cells. (C) Overexpression of Ex with GR1.Gal4 in follicle cells causes Yki:GFP to relocalise to the cytoplasm in all cells. (D) Mutation of Wts in clones marked by the absence of nuclear RFP (red) causes nuclear localisation of Yki:GFP in columnar cells. Boxed area is magnified in the panel below. (E) DMSO-treated control shows normal localisation of Yki:GFP in stretch cells and columnar cells. (F) Inhibition of Src family kinases with dasatinib has no effect on the localisation of Yki:GFP in either stretch cells or columnar cells. Arrows indicate the regions enlarged in the panels below.