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. 2018 Feb 15;145(4):dev161075. doi: 10.1242/dev.161075

Fig. 3.

Fig. 3.

β-catenin is recruited to TCF7L1-occupied sites upon WNT3A stimulation of hESCs. (A) Overlap of TCF7L1 ChIP-seq binding sites and β-catenin sites upon WNT3A stimulation from Estarás et al. (2015). 1998 overlapping sites were identified. (B) Comparison of signal intensity maps for TCF7L1 and β-catenin ±2 kb from the observed binding sites. 1998 peaks are bound by both TCF7L1 and β-catenin with strong signal intensity. Peaks bound by TCF7L1 (7795 peaks) and β-catenin (10,686 peaks) independently are also shown. (C) GREAT enrichment GO categories for the 1998 overlapping TCF7L1 and β-catenin sites. (D) Relationship of the 1998 shared binding sites to the genome with respect to the nearest gene TSS. (E) Screenshots from the UCSC Genome Browser showing overlapping TCF7L1 and β-catenin binding sites within the human NODAL and EOMES loci [β-catenin data from Estarás et al. (2015)]. Vert., vertebrate.