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. 2018 May 1;133:440–450. doi: 10.1016/j.neuropharm.2018.02.019

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© 2018 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 2 — Effect of pharmacological manipulation of MPOA CRFR1 or CRFR2 on maternal care under (A) non-stress conditions on LD 1 or (B) stress conditions on LD 7. Arched back nursing (ABN), total nursing, and licking/grooming (LG) were scored for 60 min before (basal) and (A) for 90 min after infusion (t 0 to t +90) as well as for 60 min in the afternoon (t +300 to t +330) or (B) for 60 min after infusion combined with the maternal defense test (t 0 to t +30). Dams received an acute bilateral infusion of either (i) vehicle (VEH), (ii) CRFR1 agonist (ago; h/rCRF), (iii) CRFR1 antagonist (ant; CP-154,526), (iv) CRFR2 ago (hUcn3/stresscopin), or (v) CRFR2 ant (astressin-2B) into the MPOA. Data are presented as group means + SEM. n = 6–8 rats per group. **p ≤ 0.01, *p ≤ 0.05 versus VEH-treated group; ++ p ≤ 0.01, + p ≤ 0.05 versus basal levels in the same group (two-way RM ANOVA).