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. 2018 May 1;133:440–450. doi: 10.1016/j.neuropharm.2018.02.019

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© 2018 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 5 — Effect of ICV or intra-MPOA CRFR activation on maternal care and oxytocin release in the MPOA of lactating rats. Arched back nursing (ABN) and licking/grooming (LG) (A) as well as oxytocin release in the MPOA (B) were assessed for 60 min before (t −60 to t −30) and 90 min after ICV drug infusion (t 0 to t +60) under non-stress conditions. (C) Oxytocin release in the MPOA was measured for 60 min before (t −60 to t −30), 30 min during (t 0), and 60 min after (t +30 to t +60) retrodialysis.

For (A) and (B), dams received an acute ICV infusion of either (i) vehicle (VEH), (ii) CRFR1 agonist (ago; h/rCRF), or (iii) CRFR2 ago (hUcn3/stresscopin). For (C), dams received chronic CRFR1 agonist retrodialysis into the MPOA. Data are presented as group means + SEM. n = 6–8 rats per group. **p ≤ 0.01, *p ≤ 0.05 versus VEH-treated group (two-way RM ANOVA).