Table 2.
Effect of pharmacological manipulation of MPOA CRFR1 or CRFR2 on non-maternal behaviors under stress conditions on LD 7.
| Behavior | Group | Occurrence [n] |
||
|---|---|---|---|---|
| Basal | 0 min | +30 min | ||
| Off-nest | VEH | 4.7 ± 2.2 | 10.2 ± 1.8++ | 2.7 ± 1.2 |
| CRFR1 ago | 0.5 ± 0.2 | 11.0 ± 1.0++ | 8.0 ± 1.4* | |
| CRFR1 ant | 1.3 ± 0.2 | 8.7 ± 2.3++ | 2.0 ± 1.1 | |
| CRFR2 ago | 4.5 ± 2.4 | 8.8 ± 2.0+ | 4.7 ± 1.7 | |
| CRFR2 ant | 2.9 ± 1.2 | 6.5 ± 2.2 | 4.7 ± 2.3 | |
| Locomotion | VEH | 1.3 ± 0.7 | 3.5 ± 1.8 | 0.7 ± 0.5 |
| CRFR1 ago | 0.1 ± 0.1 | 4.3 ± 0.7 | 3.0 ± 0.7 | |
| CRFR1 ant | 0.2 ± 0.1 | 3.2 ± 0.7 | 0.0 ± 0.0 | |
| CRFR2 ago | 0.4 ± 0.3 | 4.0 ± 1.6 | 1.7 ± 0.6 | |
| CRFR2 ant | 0.6 ± 0.2 | 2.8 ± 0.9 | 0.8 ± 0.3 | |
| Self-grooming | VEH | 0.7 ± 0.2 | 1.5 ± 0.6 | 0.5 ± 0.3 |
| CRFR1 ago | 0.3 ± 0.1 | 5.0 ± 0.8**++ | 2.5 ± 1.3** | |
| CRFR1 ant | 0.2 ± 0.1 | 2.0 ± 0.9+ | 0.0 ± 0.0 | |
| CRFR2 ago | 0.8 ± 0.4 | 2.2 ± 0.8 | 0.7 ± 0.3 | |
| CRFR2 ant | 0.5 ± 0.2 | 1.5 ± 0.4 | 1.0 ± 0.6 | |
| Sleeping/ resting |
VEH | 1.0 ± 1.0 | 3.5 ± 2.2 | 1.3 ± 1.3 |
| CRFR1 ago | 0.0 ± 0.0 | 0.5 ± 0.5 | 0.5 ± 0.5 | |
| CRFR1 ant | 0.3 ± 0.3 | 1.8 ± 1.3 | 1.7 ± 1.0 | |
| CRFR2 ago | 1.9 ± 1.3 | 0.0 ± 0.0 | 1.5 ± 1.5 | |
| CRFR2 ant | 0.4 ± 0.3 | 1.7 ± 1.7 | 2.5 ± 2.5 | |
The occurrence of all off-nest behaviors was scored for 60 min before (averaged as basal) and 60 min after the infusion combined with the maternal defense test (immediately before t 0 min). Off-nest behavior is further divided into locomotion (including digging/burrowing and any explorative behavior in the home cage), self-grooming, and sleeping/resting. For details on treatments, see the Fig. 2 legend. Data are presented as group means ± SEM. n = 6 rats per group. **p ≤ 0.01, *p ≤ 0.05 versus VEH; ++ p ≤ 0.01, + p ≤ 0.05 versus basal.