Table 1.
Demographic and baseline clinical characteristics of patients prior to CF-LVAD implantation
| Characteristics | Pre-implant HF patients (n = 51) | ||
|---|---|---|---|
| Non-bleeder group(n = 37) | Bleeder group(n =14) | p-value | |
| Demography | |||
| Age in years | |||
| Mean ± SD | 59.2 ± 10.7 | 59.5 ± 12.6 | 0.92 |
| Median (IQR) | 60.0 (31.0 – 76.0) | 63.5 (25.0 – 70.0) | 0.59 |
| Sex, n (% male) | 36 (97.3 %) | 11 (78.6 %) | 0.10 |
| Age in years | |||
| Caucasian white, n (%) | 28 (75.7 %) | 6 (42.9 %) | 0.06 |
| Black, n (%) | 9 (24.3 %) | 8 (57.1 %) | |
| Height in meter | |||
| Mean ± SD | 1.8 ± 0.1 | 1.7 ± 0.1 | 0.25 |
| Median (IQR) | 1.8 (1.6 – 1.9) | 1.7 (1.6 – 1.9) | 0.17 |
| Weight in kilograms | |||
| Mean ± SD | 99.0 ± 19.4 | 81.3 ± 17.4 | 0.01* |
| Median (IQR) | 99.8 (60.0 – 127.9) | 80.3 (53.0 – 112.0) | 0.01* |
| Body mass index (BMI) (kg/m2) | |||
| Mean ± SD | 30.7 ± 5.0 | 26.6 ± 4.9 | 0.02* |
| Median (IQR) | 31.2 (20.8 – 39.0) | 26.1 (19.5 – 34.3) | 0.02* |
| Body surface area (BSA) (m2) | |||
| Mean ± SD | 2.2 ± 0.3 | 2.0 ± 0.3 | 0.02* |
| Median (IQR) | 2.3 (1.6 – 2.5) | 2.0 (1.6 – 2.4) | 0.03* |
| History of smoking, n (%) | 10 (27.0 %) | 3 (21.4 %) | 0.96 |
| History of substance abuse | |||
| Ethyl alcohol abuse, n (%) | 7 (18.9 %) | 2 (14.3 %) | 0.70 |
| Drug abuse, n (%) | 9 (24.3 %) | 3 (21.4 %) | 0.83 |
|
| |||
| Vital signs | |||
| Systolic blood pressure (mmHg) | |||
| Mean ± SD | 103.1 ± 10.7 | 107.7 ± 11.9 | 0.28 |
| Median (IQR) | 105.0 (79.0 – 129.0) | 109.0 (86.0 – 131.0) | 0.13 |
| Diastolic blood pressure (mmHg) | |||
| Mean ± SD | 62.1 ± 8.6 | 67.6 ± 13.5 | 0.17 |
| Median (IQR) | 63.0 (46.0 – 83.0) | 64.0 (60.0 – 105.0) | 0.43 |
|
| |||
| Etiology of heart disease | |||
| Ischemic cardiomyopathy, n (%) | 21 (56.8 %) | 10 (71.4 %) | 0.53 |
| Non-ischemic cardiomyopathy, n (%) | 16 (43.2 %) | 4 (28.6 %) | 0.53 |
|
| |||
| Echocardiographic parameters | |||
| Left ventricular end diastolic diameter (mm) | |||
| Mean ± SD | 66.1 ± 8.6 | 67.4 ±11.7 | 0.76 |
| Median (IQR) | 63.0 (53.0 – 88.0) | 67.5 (52.0 – 88.0) | 0.70 |
| Left ventricular ejection fraction (%) | |||
| Mean ± SD | 13.7 ± 3.3 | 15.0 ± 5.6 | 0.37 |
| Median (IQR) | 15.0 (10.0 – 20.0) | 12.5 (10.0 – 25.0) | 0.66 |
Demographic and clinical parameters of non-bleeder versus bleeder groups of HF patients were statistically compared by Mann-Whitney ‘U’ test (for median values with IQR), χ2-test (for results presented as percentages) and Student’s t-test (for results presented as mean ± SD) as applicable,
*
p<0.05 were considered significant.