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Soluble HA concentration measured via ELISA for (A) U87 and (B) U87vIII cells. A compensatory production of soluble HA was observed between +/− HAMA as early as 6 hours in culture. Soluble HA concentrations were elevated under hypoxia independent of the matrix composition. ^ significant (p < 0.05) for +/− hypoxia; * significant (p < 0.05) for +/− HAMA.
