TABLE 4.
Changes in CBC counts during treatment
| Treatment groupa | Group differenceb | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PLACEBO (n=14) | RAPA (n=11) | |||||||||
| Pre | Post | P value | Difference (95%CI) | Pre | Post | P value | Difference (95%CI) | P value | Difference (95%CI) | |
| RBC | 4.42 ± 0.47 | 4.45 ± 0.43 | 0.55 | 0.03 [−0.08, 0.15] | 4.43 ± 0.48 | 4.31 ± 0.53 | 0.043 | −0.12 [−0.24, 0] | 0.05 | 0.15 [0, 0.31] |
| MCV | 93.75 ± 4.2 | 93.74 ± 4.35 | 0.99 | −0.01 [−0.9, 0.89] | 94 ± 3.23 | 91.36 ± 4.19 | <0.001 | −2.64 [−3.52, −1.75] | <0.001 | 2.63 [1.44, 3.82] |
| MCH | 31.34 ± 1.89 | 31.2 ± 1.73 | 0.5 | −0.14 [−0.58, 0.3] | 31.47 ± 1.27 | 30.56 ± 1.29 | <0.001 | −0.91 [−1.3, −0.51] | 0.009 | 0.77 [0.21, 1.33] |
| MCHC | 33.41 ± 0.78 | 33.26 ± 0.6 | 0.31 | −0.15 [−0.46, 0.16] | 33.47 ± 0.56 | 33.46 ± 0.43 | 0.96 | −0.01 [−0.36, 0.35] | 0.52 | −0.14 [−0.58, 0.3] |
| RDW | 13.49 ± 0.82 | 13.53 ± 0.86 | 0.63 | 0.04 [−0.12, 0.19] | 13.73 ± 0.77 | 12.85 ± 0.44 | <0.001 | −0.88 [−1.14, −0.63] | <0.001 | 0.92 [0.63, 1.2] |
| WBC | 5.51 ± 1.26 | 5.39 ± 1.16 | 0.64 | −0.12 [−0.68, 0.43] | 5.6 ± 1.22 | 4.9 ± 0.81 | 0.09 | −0.7 [−1.54, 0.14] | 0.22 | 0.58 [−0.38, 1.54] |
| HgB | 13.81 ± 1.53 | 13.98 ± 1.63 | 0.33 | 0.16 [−0.19, 0.51] | 13.94 ± 1.35 | 13.12 ± 1.22 | 0.003 | −0.82 [−1.29, −0.35] | 0.001 | 0.98 [0.43, 1.54] |
| HCT | 41.29 ± 4.13 | 41.96 ± 4.54 | 0.21 | 0.67 [−0.42, 1.76] | 41.57 ± 3.79 | 39.24 ± 3.75 | 0.002 | −2.34 [−3.57, −1.1] | <0.001 | 3.01 [1.45, 4.56] |
| PLTS | 197.36 ± 37.88 | 215.21 ± 48.32 | 0.009 | 17.86 [5.17, 30.54] | 189.73 ± 41.9 | 211.82 ± 58.85 | 0.06 | 22.09 [−1.14, 45.32] | 0.73 | −4.23 [−29.58, 21.12] |
. To compare changes in CBC counts over the treatment period, the “Pre” values (taken before treatment was initiated) were subtracted from the “Post” values to obtain the “Difference” within a treatment group and were assessed by paired t-tests to identify any statistically significant changes in either the RAPA or Placebo groups. The p-values are shown. The direction of the change is indicated in the “Difference column” where a positive number indicates a higher mean value after 6–8 weeks of treatment and a negative value reflects a lower value after treatment. The 95% confidence interval is shown in brackets. The mean values measured are shown ± standard deviation. Individual values for several of these markers and some additional data are shown graphically in Figure 1D,E,F.
. To determine whether there was a difference in the RAPA vs. the placebo group, the mean “difference” values were compared using a Welch’s t-test. The resulting p-values are shown. The difference mean changes seen in the RAPA and placebo groups are shown with the 95% confidence interval in brackets.