TABLE 5.
Changes in metabolic markers during treatment
| Treatment groupa | Group differenceb | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PLACEBO | RAPA | |||||||||
| Pre | Post | P value | Difference (95%CI) | Pre | Post | P value | Difference (95%CI) | P value | Difference (95%CI) | |
| Glucose | 96.43 ± 10.86 | 97.71 ± 12.19 | 0.56 | 1.29 [−3.35, 5.92] | 99.64 ± 10.31 | 97.45 ± 10.93 | 0.42 | −2.18 [−7.93, 3.56] | 0.31 | 3.47 [−3.51, 10.44] |
| AIC | 5.67 ± 0.44 | 5.69 ± 0.36 | 0.68 | 0.02 [−0.09, 0.13] | 5.81 ± 0.4 | 6 ± 0.43 | 0.032 | 0.19 [0.02, 0.35] | 0.07 | −0.17 [−0.34, 0.01] |
| HDL | 55.83 ± 14.79 | 57.92 ± 13.91 | 0.13 | 2.08 [−0.71, 4.88] | 55.22 ± 15.74 | 58.11 ± 16.58 | 0.18 | 2.89 [−1.62, 7.39] | 0.73 | −0.81 [−5.79, 4.18] |
| LDL | 95.5 ± 31.46 | 103.9 ± 24.45 | 0.14 | 8.4 [−3.06, 19.86] | 89.47 ± 17.75 | 100.51 ± 23.52 | 0.23 | 11.04 [−8.7, 30.79] | 0.8 | −2.64 [−24.19, 18.9] |
| TRIG | 116.25 ± 78.74 | 123.42 ± 100.14 | 0.4 | 7.17 [−11.05, 25.38] | 92.78 ± 48.33 | 131.22 ± 71.53 | 0.05 | 38.44 [0.04, 76.85] | 0.12 | −31.28 [−71.83, 9.27] |
| VLDL | 19.82 ± 10.39 | 21.27 ± 13.02 | 0.26 | 1.45 [−1.24, 4.15] | 18.44 ± 9.76 | 26.09 ± 14.61 | 0.06 | 7.64 [−0.3, 15.59] | 0.12 | −6.19 [−14.33, 1.95] |
. To compare changes in metabolic markers over the treatment period, the “Pre” values (taken before treatment was initiated) were subtracted from the “Post” values to obtain the “Difference” within a treatment group and were assessed by paired t-tests to identify any statistically significant changes in either the RAPA or Placebo groups. The p-values are shown. The direction of the change is indicated in the “Difference column” where a positive number indicates a higher mean value after 6–8 weeks of treatment and a negative value reflects a lower value after treatment. The 95% confidence interval is shown in brackets. The mean values measured are shown ± standard deviation. Individual values for several of these markers and some additional data are shown graphically in Figure 1G,H,J,K,L.
. To determine whether there was a difference in the RAPA vs. the placebo group, the mean “difference” values were compared using a Welch’s t-test. The resulting p-values are shown. The difference mean changes seen in the RAPA and placebo groups are shown with the 95% confidence interval in brackets.