FIGURE 7.

Decreased latency to LORR observed in β-arrestin 1 KO mice but duration of LORR not affected by β-arrestin 1 expression. Following 3.8 g/kg 20% ethanol administration (i.p.), no sex effect was observed for latency to LORR (n = 26 males, n = 25 females), although a genotype effect was observed in both male (n = 7 WT, n = 8 HET, n = 10 KO) and female mice (n = 8 WT, n = 8 HET, n = 8 KO), with decreased latency was observed in mice lacking β-arrestin 1 expression (A). Duration of LORR was not affected by sex or β-arrestin 1 genotype alone, nor were differences observed by genotype + sex (B). Significance by two-way ANOVA with multiple comparisons (Tukey within sex, Sidek between genotype), ^∗p < 0.05, ^∗∗p < 0.01; data represented as mean ± SEM.