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. 2018 Mar 20;9:498. doi: 10.3389/fimmu.2018.00498

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Copyright © 2018 Rudolph, McArthur, Barnes, Magder, Chen and Sztein.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD8⁺ T effector memory response. (A) Scatter plot showing the net percentages of CD8⁺ T_EM producing MIP-1β, CD107a, TNF-α, IL-2, IL-17A, IFN-γ, and Granzyme B (GzmB) following SEB stimulation. Results are shown for the following populations: 6–15-year-old pediatric (n = 11), 16–17-year-old pediatric (n = 9), and adult (n = 14) participants. Bars represent medians with whiskers indicating interquartile ranges. Scatter plot statistics were analyzed by unpaired t-test (*p < 0.05; **p < 0.01; ***p < 0.001). Line graphs represent linear regression with 95% confidence intervals among CD8⁺ T effector memory cell mono- (B,C), bi- (D,E), tri- (F,G), and >3- (H,I) functional populations following SEB stimulation within participants between the ages of 6–17 (n = 20) and 20–65 (n = 14) years old. Line graph statistics were analyzed by Spearman r correlation (*p < 0.05; ***p < 0.001).