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. 2018 Mar 20;9:498. doi: 10.3389/fimmu.2018.00498

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Copyright © 2018 Rudolph, McArthur, Barnes, Magder, Chen and Sztein.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Highly multifunctional CD8⁺ T cell functional states. Scatter plots showing the percentages of highly multifunctional CD8⁺ T cells as defined by CITRUS node isolation. (A) T_EM and (B) T_EMRA cells within the chosen highly multifunctional nodes (see Figure 6) showing proportions of cytotoxic (CD27⁻) or proliferative (CD27⁺ and Ki67⁺) multifunctional CD8⁺ T cells in adults and children. (C) T_EM and (D) T_EMRA populations showing highly multifunctional CD27⁺. CD27⁻, and Ki67⁺ cells from within the total CITRUS sampled CD8⁺ memory T cell subsets, exhibiting the proportion of highly multifunctional cytotoxic or proliferative phenotypes from within the each memory subset. Populations split among 6–15-year-old pediatric (n = 11) and adult (n = 14) participants. Bars represent medians with whiskers indicating interquartile ranges. Scatter plot statistics were analyzed by unpaired t-test (*p < 0.05; **p < 0.01; and ***p < 0.001).