Table 1.
The usage of genetically engineered Mesenchymal stem cells for target delivery of therapeutic agents with anti-tumor activity.
| Agent | Mechanism of action | Model | Reference |
|---|---|---|---|
| IFN-α | Immunostimulation, apoptosis induction, angiogenesis suppression | Immunocompetent mouse model of metastatic melanoma | Ren et al., 2008a |
| IFN-β | Increased activity of NK cells, inhibition of | Mouse 4T1 breast tumor model | Ling et al., 2010 |
| Stat3 signaling | Mouse prostate cancer lung metastasis model | Ren et al., 2008b | |
| PC-3 (prostate cancer) xenograft model | Wang et al., 2012 | ||
| PANC-1 (pancreatic carcinoma) xenograft model | Kidd et al., 2010 | ||
| IFN-γ | Immunostimulation, apoptosis induction | In vitro human leukemia cell line K562 | Li et al., 2006 |
| TRAIL | Caspase activation, apoptosis induction | Orthotopic model of Ewing sarcoma | Guiho et al., 2016 |
| Subcutaneous model of lung cancer | Mohr et al., 2008; Yan et al., 2016 | ||
| Xenograft model of human malignant mesothelioma | Sage et al., 2014; Lathrop et al., 2015 | ||
| Colo205 (colon cancer) xenograft tumor model | Marini et al., 2017 | ||
| Xenograft model of human myeloma | Cafforio et al., 2017 | ||
| Xenograft model of human tongue squamous cell carcinoma (TSCC) | Xia et al., 2015 | ||
| Eca-109 (esophageal cancer) xenograft model | Li et al., 2014 | ||
| Xenograft model of human glioma |
Kim et al., 2010; Choi et al., 2011; Wang et al., 2017 |
||
| IL-2 | Immunostimulation | Rat glioma model | Nakamura et al., 2004 |
| IL-12 | Immune system cell activation | Liver cancer H22 and MethA ascites models | Han et al., 2014 |
| Mouse model bearing subcutaneous SKOV3 (ovarian carcinoma) tumor explants | Zhao et al., 2011 | ||
| Xenograft model of human glioma | Hong et al., 2009; Ryu et al., 2011 | ||
| IL-21 | Immunostimulation | Mouse model of B-cell lymphoma | Kim et al., 2015 |
| A2780 (ovarian cancer) xenograft model | Hu et al., 2011 | ||
| PTEN | Induction of G(1)-phase cell cycle arrest | In vitro glioma cell line | Yang Z.S. et al., 2014; Guo et al., 2016 |
| CX3CL1 | Cytotoxic T cells and NK cells activation | Mice bearing lung metastases of C26 (colon carcinoma) and B16F10 (skin melanoma) cells | Xin et al., 2007 |
| HSV-TK/GCV | Drug precursors transformation | 9L (glioma) xenograft model | Uchibori et al., 2009 |
| In vitro glioma cell lines 8-MG-BA, 42-MG-BA and U-118 MG | Matuskova et al., 2010 | ||
| CD/5-FC | Drug precursors transformation | Subcutaneous model of melanoma or colon cancer | Kucerova et al., 2007, 2008 |
| Cal72 (osteosarcoma) xenograft model | NguyenThai et al., 2015 | ||
| NK4 | Apoptosis induction, angiogenesis and | C-26 lung metastasis model | Kanehira et al., 2007 |
| lymphangiogenesis suppression | Nude mice bearing gastric cancer xenografts | Zhu et al., 2014 | |
| MHCC-97H (liver carcinoma) xenograft model | Cai et al., 2017 | ||
| Oncolytic viruses | Tumor destruction by virus replication | Orthotopic breast and lung tumors | Hakkarainen et al., 2007 |
| Mouse glioblastoma multiforme models | Duebgen et al., 2014 | ||
| A375N (melanoma) tumor xenografts | Bolontrade et al., 2012 | ||
| PEDF | Inhibiting tumor angiogenesis, inducing apoptosis, | Lewis lung carcinoma (LLC) xenograft model | Chen et al., 2012 |
| and restoring the VEGF-A/sFLT-1 ratio | Mice bearing U87 gliomas | Su et al., 2013 | |
| CT26 CRPC model | Yang et al., 2016 | ||
| Apoptin | Tumor destruction, caspase 3 activation | HepG2 (hepatocellular carcinoma) tumor xenografts | Zhang et al., 2016 |
| Lung carcinoma xenograft model | Du et al., 2015 | ||
| HNF4-α | Wnt/β-catenin pathway inhibition | SK-Hep-1 (hepatocellular carcinoma) tumor xenografts | Wu et al., 2016 |
| miR-124 | Increase the differentiation of glioma stem cells | Glioma tumor cells in a spheroid cell culture system | Lee et al., 2013 |
| by targeting SCP-1 or CDK6 | In vitro human glioblastoma multiforme cell line | Sharif et al., 2017 | |
| miR-145 | Sox2 and Oct4 expression inhibition | Glioma tumor cells in a spheroid cell culture system | Lee et al., 2013 |