Table 1.
An account of mode of exosome biogenesis and proteins involved in the process of biogenesis.
| Sl. No. | Mode of biogenesis | Proteins involved | Cell line used | Reference |
|---|---|---|---|---|
| 1 | Endosomal sorting complex required for transport (ESCRT) dependent | hsc73, annexin II, Gi2α | Murine DCs | (5) |
| 2 | ESCRT dependent | hsc70, alix | Rat erythrocytes | (6) |
| 3 | ESCRT dependent | CHMP4b, SKD1, alix | HeLa, HEK293 cells | (7) |
| 4 | ESCRT dependent | TSG101, VPS4b | DC2.4 cells | (8) |
| 5 | ESCRT dependent | Syndecan heparin sulfate, syntanin, alix | MCF-7 cells | (9) |
| 6 | ESCRT dependent | Hrs, STAM, TSG 101, VPS4 | HeLa cells | (10) |
| 7 | ESCRT dependent | ESCRT, VPS34, VPS4 | Mouse embryonic stem cells | (11) |
| 8 | ESCRT independent | Ceramide | Oli-neu cells | (12) |
| 9 | ESCRT independent | Rab27a, Rab27b | HeLa cells | (13) |
| 10 | ESCRT independent | Rab35, Rab11, TBC1D10A-C | Oli-neu cells | (14) |
| 11 | ESCRT independent | Sphingomyelinase 2 | 4T1 cells | (15) |
| 12 | ESCRT independent | Sphingomyelinase 2 | GT1–7 cells | (16) |
| 13 | ESCRT independent | Sphingosine1 phosphate receptor | HeLa cells | (17) |
| 14 | ESCRT independent and Ca2+ dependent | Transferrin receptors | K562 cells | (18) |
| 15 | ESCRT independent and senescence associated | P53 | LNCaP, 22Rv1, DU14 cells | (19) |