Table 4.
Ongoing and completed clinical trials involving exosomes as therapeutics or diagnostic agents [Source: National Institute of Health (NIH) clinical trial registry].
| S.No | Title of the study | Type of cancer | Study design | Starting date | NCT number |
|---|---|---|---|---|---|
| 1 | Interrogation of exosome-mediated intercellular signaling in patients with pancreatic cancer | Pancreatic cancer | Prospective trial: observational | March 2015 | NCT02393703 |
| 2 | Circulating exosome RNA in lung metastases of primary high-grade osteosarcoma | Osteosarcoma | Prospective trial: observational | May 2017 | NCT03108677 |
| 3 | ncRNAs in exosomes of cholangiocarcinoma | Cholangio carcinoma | Prospective translational study with preclinical and clinical phases | May 2017 | NCT03102268 |
| 4 | Edible plant exosome ability to prevent oral mucositis associated with chemoradiation treatment of head and neck cancer | Head and neck cancer | Intervention model: parallel assignment | August 2012 | NCT01668849 |
| 5 | Exosome testing as a screening modality for human papillomavirus-positive oropharyngeal squamous cell carcinoma | Oropharyngeal squamous cell carcinoma | Observational, single-institution pilot/feasibility study | February 2015 | NCT02147418 |
| 6 | Diagnostic accuracy of circulating tumor cells (CTCs) and onco-exosome quantification in the diagnosis of pancreatic cancer – PANC-CTC (PANC-CTC) | Pancreatic cancer | Prospective trial: observational | February 2017 | NCT03032913 |
| 7 | Metformin hydrochloride in affecting cytokines and exosomes in patients with head and neck cancer | Head and neck cancer | Intervention model: parallel assignment | March 2017 | NCT03109873 |
| 8 | Study of molecular mechanisms implicated in the pathogenesis of melanoma. Role of Exosomes (EXOSOMES) | Melanoma | Intervention model: single Group assignment | December 2014 | NCT02310451 |
| 9 | Olmutinib trial in T790M (+) NSCLC patients detected by liquid biopsy using BALF extracellular vesicular DNA | NSCLC | Intervention model: single Group assignment | July 2017 | NCT03228277 |
| 10 | Study investigating the ability of plant exosomes to deliver curcumin to normal and colon cancer tissue | Colon cancer | Intervention model: factorial assignment | January 2011 | NCT01294072 |
| 11 | Effect of plasma derived exosomes on cutaneous wound healing | Ulcer | Intervention model: single group assignment | September 2015 | NCT02565264 |
| 12 | Circulating exosomes as potential prognostic and predictive biomarkers in advanced gastric cancer patients (“EXO-PPP Study”) | Gastric cancer | Observational model: case control | January 2013 | NCT01779583 |
| 13 | Clinical research for the consistency analysis of PD-L1 in cancer tissue and plasma exosome (RadImm01) | Non-small cell lung cancer (NSCLC) | Intervention model: single group assignment | October 2016 | NCT02890849 |
| 14 | Clinical validation of a urinary exosome gene signature in men presenting for suspicion of prostate cancer | Prostate cancer | Observational model: cohort | May 2014 | NCT02702856 |
| 15 | Trial of a vaccination with tumor antigen-loaded dendritic cell-derived exosomes (CSET 1437) | Unresectable non-small cell lung cancer responding to induction chemotherapy | Intervention model: single Group assignment, Phase II trial | December 2009 | NCT01159288 |
| 16 | Clinical research for the consistency analysis of PD-L1 in lung cancer tissue and plasma exosome before and after radiotherapy (RadImm02) | Lung cancer | Intervention model: single Group assignment | October 2016 | NCT02869685 |
| 17 | Anaplastic thyroid cancer and follicular thyroid cancer-derived exosomal analysis via treatment of lovastatin and vildagliptin and pilot prognostic study via urine exosomal biological markers in thyroid cancer patients | Thyroid cancer | Observational model: cohort | August 2016 | NCT02862470 |