Table 1.
Clinicopathological parameters of 475 patients with papillary thyroid carcinoma (PTC) stratified by the presence of chronic lymphocytic thyroiditis (CLT)
| Variables | PTC only (%) | PTC with CLT (%) | Odds ratio (95% CI) | p value |
|---|---|---|---|---|
| Total n | 309 (65) | 166 (35) | ||
| Sex | ||||
| Female | 258 (81.2) | 146 (88) | 1.67 (0.98–2.9) | 0.061 |
| Male | 58 (18.8) | 20 (12) | ||
| Age | ||||
| Mean (SD), years | 49.3±13.87 | 48±13.78 | ||
| Patients <45 years | 128 (41.4) | 78 (47) | 0.24 | |
| Patients >45 years | 181 (58.6) | 88 (53) | ||
| Thyroglobulin antibody | 58 (18.7) | 70 (42.2) | 3.51 (2.3–5.8) | <0.0001 |
| Mean tumor size (SD), cm | 2.06 (1.62) | 1.96 (1.53) | 0.08 | |
| Vascular invasion | 35 (11.3) | 20 (12) | 1.07 (0.6–1.9) | 0.83 |
| Capsular invasion | 85 (27.5) | 39 (23.5) | 0.81 (0.5–1.3) | 0.34 |
| Extrathyroidal extension | 64 (20.7) | 39 (23.5) | 1.17 (0.74–1.8) | 0.49 |
| LN metastasis | 75 (24.3) | 46 (27.7) | 1.19 (0.78–1.8) | 0.41 |
| Lateral LN | 25 (8.1) | 19 (11.4) | 1.47 (0.8–2.8) | 0.23 |
| Multifocality | 127 (41.1) | 82 (49.4) | 1.4 (0.96–2.0) | 0.08 |
| Bilaterality | 119 (38.5) | 67 (40.1) | 1.1 (0.72–1.5) | 0.73 |
| Distant metastasis | 6 (1.94) | 1 (0.6) | 0.31 (0.04–2.6) | 0.27 |
| Aggressive histology | 10 (3.2) | 8 (4.8) | 1.5 (0.6–3.9) | 0.39 |
| Stage | ||||
| I | 192 (62.2) | 120 (71.9) | 1.34 (1.02–1.8) | 0.027 |
| II | 47 (15.2) | 16 (9.6) | 0.59 (0.33–1.08) | 0.09 |
| III | 51 (16.5) | 24 (14.4) | 0.85 (0.5–1.4) | 0.5 |
| IV | 19 (6.1) | 6 (3.6) | 0.57 (0.2–1.5) | 0.24 |
| Persistent disease | 24 (7.8) | 3 (1.8) | 0.22 (0.06–0.73) | 0.014 |
| Recurrent disease | 1 (0.3) | 3 (1.8) | 5.67 (0.58–54.9) | 0.13 |
| Mean follow-up (SD), months | 25.5 (19.5) | 24.6 (16.3) | 0.08 |
Numbers of patients are shown except where indicated otherwise. LN, lymph node metastasis. Aggressive histological subtypes include insular, diffuse sclerosing, solid, and tall cell variants.