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. 2017 Nov 3;89(4):374–381. doi: 10.1136/jnnp-2017-316365

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Whole-brain-based spatial statistics (WBSS) for longitudinal differences in patients with ALS vs controls. (A) Slice-wise representation and sagittal projectional view of significant (p<0.05, FDR corrected) longitudinal alterations of fractional anisotropy (FA) values. (B) Significant longitudinal alterations (calculated by WBSS of 67 patients with ALS vs 31 controls) and ALS-related tract structures. CST, corticospinal tract.