FIG 7.

CodY-enhanced PMN killing is dependent on the Sae TCS. Primary human PMNs were intoxicated with supernatants obtained from codY null mutants at either 3 h (A) or 5 h (B) following subculture. Intoxication experiments were performed on two independent occasions, with a total of four blood donors. Statistical analysis was performed by ANOVA with Dunnett's multiple-comparison test. Asterisks indicate P values for comparisons between results for the wild type (LAC) and the codY null mutant (**, P < 0.01; ***, P < 0.001; ****, P < 0.0001). Error bars represent the standard errors of the means.