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Working model of how nutritional regulation controls SaeR/S. CodY integrates the nutritional status of the cell with host cues at the sae P1 promoter. Under conditions of nutrient excess, sae P1 transcription is repressed. As nutrients become depleted, CodY repression is lifted, eventually resulting in an increase in SaeR/S activity and the expression of exoproteins to damage host tissue. This allows S. aureus to scavenge nutrients from the host environment.
