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Hypothetical model of CnpB-controlled CRISPR-Cas system in TB complex mycobacteria. The meanings of the symbols in the ΔcnpB strain diagram are identical to those in the WT diagram. In this model, more nanoRNAs were accumulated in the ΔcnpB strain than in the WT, which induces the expression of both pre-crRNA and the cas genes. Eventually, more crRNAs were generated in the ΔcnpB strain than in the WT.
