TABLE 1.
Gene regulation by deletion of cnpB in M. tuberculosisa
| Gene | Function | Fold change (log2) | P value |
|---|---|---|---|
| Rv2913c | N-Acyl-d-glutamate amidohydrolase | −2.1 | 0.00005 |
| Rv0792c | FAD-dependent NAD(P)-disulfide oxidoreductase | −1.9 | 0.00005 |
| Rv2912c | Transcriptional regulator; TetR family | −1.8 | 0.00005 |
| Rv0791c | N5,N10-Methylene tetrahydromethanopterin reductase | −1.8 | 0.00005 |
| Rv2009 | Hypothetical protein | −1.6 | 0.00005 |
| Rv2466c | Hypothetical protein | −1.6 | 0.00005 |
| Rv0654 | Lignostilbene-α,β-dioxygenase | −1.5 | 0.00005 |
| Rv1807 | PPE family protein | −1.4 | 0.00005 |
| Rv3252c | Alkane-1 monooxygenase | −1.4 | 0.00005 |
| Rv3463 | N5,N10-methylene tetrahydromethanopterin reductase | −1.4 | 0.00005 |
| Rv1285 | Sulfate adenylyltransferase subunit 2 | −1.3 | 0.00005 |
| Rv1808 | PPE family protein | −1.3 | 0.00005 |
| Rv0768 | Aldehyde dehydrogenase | −1.3 | 0.00005 |
| Rv1168c | PPE family protein | −1.2 | 0.00005 |
| Rv3054c | NADPH-quinone oxidoreductase | −1.2 | 0.00005 |
| Rv0251c | Heat shock protein Hsp | −1.1 | 0.00005 |
| Rv0331 | Oxidoreductase (flavoprotein) | −1.1 | 0.00005 |
| Rv1169c | PE family of proteins | −1.1 | 0.00005 |
| Rv0105c | LSU ribosomal protein L28p | −1.1 | 0.00002 |
| Rv2010 | Toxin 1; PIN domain | −1.1 | 0.00005 |
| Rv3174 | Putative oxidoreductase | −1.1 | 0.00160 |
| Rv3615c | RD1-dependent secreted antigen | −1.1 | 0.00005 |
| Rv1130 | 2-Methylcitrate dehydratase | −1.1 | 0.00005 |
| Rv1554 | Fumarate reductase subunit C | −1.0 | 0.00165 |
| Rv0384c | ClpB protein | −1.0 | 0.00005 |
| Rv2025c | Cobalt-zinc-cadmium resistance protein | −1.0 | 0.00005 |
| Rv1286 | Sulfate adenylyltransferase subunit 1 | −1.0 | 0.00035 |
| Rv1805c | Hypothetical protein | −1.0 | 0.00005 |
| Rv3614c | ESX-1 secretion system protein | −1.0 | 0.00005 |
| Rv1552 | Succinate dehydrogenase flavoprotein subunit | −1.0 | 0.00005 |
| Rv3616c | ESX-1 secretion system protein | −1.0 | 0.00005 |
| Rv1809 | PPE family protein | −1.0 | 0.00005 |
| Rv1639c | Hypothetical protein | −1.0 | 0.00005 |
| Rv3824c | Polyketide synthase-associated protein PapA1 | −1.0 | 0.00005 |
| Rv3171c | Nonheme haloperoxidase Hpx | −1.0 | 0.00005 |
| Rv2006 | Uncharacterized glycosyl hydrolase | 1.0 | 0.00005 |
| Rv1757c | Mobile element protein | 1.0 | 0.00040 |
| Rv3000 | YbbM seven-transmembrane-helix protein | 1.0 | 0.00005 |
| Hypothetical protein | 1.1 | 0.00005 | |
| Rv1370c | Mobile element protein | 1.1 | 0.00055 |
| Rv2815c | Mobile element protein | 1.1 | 0.00010 |
| Rv0342 | Isoniazid-inducible protein IniA | 1.1 | 0.00005 |
| Hypothetical protein | 1.1 | 0.00005 | |
| Rv1955 | Hypothetical protein | 1.2 | 0.00005 |
| Rv2835c | Glycerol-3-phosphate ABC transporter UgpA | 1.3 | 0.00005 |
| Rv3862c | Transcriptional regulator WhiB-like WhiB6 | 1.3 | 0.00010 |
| Rv2450c | Putative saccharopine dehydrogenase | 1.3 | 0.00005 |
| Rv2816c | CRISPR-associated protein Cas2 | 1.5 | 0.00005 |
| Rv0341 | Isoniazid-inducible protein IniB | 1.8 | 0.00005 |
| Rv2836c | Putative DNA damage-inducible protein F | 2.4 | 0.00005 |
| Rv2817c | CRISPR-associated protein Cas1 | 3.2 | 0.00005 |
| Hypothetical protein | 3.7 | 0.00005 | |
| Hypothetical protein | 4.9 | 0.00005 | |
| Rv2819c | CRISPR-associated protein; Csm5 family | 5.0 | 0.00005 |
| Rv2818c | CRISPR-associated protein Csm6 | 5.3 | 0.00005 |
| Rv2822c | CRISPR-associated protein; Csm2 family | 5.5 | 0.00005 |
| Rv2823c | CRISPR-associated protein; Csm1 family | 5.5 | 0.00005 |
| Rv2820c | CRISPR-associated RAMP protein; Csm4 family | 5.5 | 0.00005 |
| Rv2824c | CRISPR-associated protein Cas6 | 5.6 | 0.00005 |
| Rv2821c | CRISPR-associated RAMP Csm3 | 5.7 | 0.00005 |
| Hypothetical protein | 5.8 | 0.00005 |
a
Genes listed without gene names were not annotated in the M. tuberculosis H37Rv genome reported by Cole et al. (25). The mean fold change and the P value of each gene were directly exported from the analysis with RNA-Rocket.