Table 1.
The list of drugs with gene expression in cardiomyocytes and their cardiotoxicity classification
| Drug name | Classification | Referencea |
|---|---|---|
| Afatinib | 0 | Drugs@FDA and literature search |
| Alendronate | 0 | Drugs@FDA and literature search |
| Amiodarone | 1 | Drugs@FDA |
| Axitinib | 1 | Drugs@FDA |
| Bosutinib | 0 | Drugs@FDA and literature search |
| Cefuroxime | 0 | Drugs@FDA and literature search |
| Crizotinib | 0 | Drugs@FDA and literature search |
| Cyclosporine | 0 | Drugs@FDA and literature search |
| Cytarabine | 1 | NIH DailyMed |
| Dasatinib | 1 | Drugs@FDA |
| Diclofenac | 1 | Drugs@FDA |
| Domperidone | 0a | Not approved by FDA |
| Doxorubicin | 1 | Drugs@FDA |
| Diethylpropion | 0 | Drugs@FDA and literature search |
| Erlotinib | 0 | Drugs@FDA and literature search |
| Gefitinib | 0 | Drugs@FDA and literature search |
| Imatinib | 1 | Drugs@FDA |
| Lapatinib | 0 | Drugs@FDA |
| Methotrexate | 0 | Drugs@FDA and literature search |
| Olmesartan | 0 | Drugs@FDA and literature search |
| Paroxetine | 1 | Drugs@FDA |
| Ponatinib | 1 | Drugs@FDA |
| Regorafenib | 0 | Drugs@FDA and literature search |
| Ruxolitinib | 0 | Drugs@FDA and literature search |
| Sorafenib | 1 | Drugs@FDA |
| Sunitinib | 1 | Drugs@FDA |
| Tofacitinib | 0 | Drugs@FDA and literature search |
| Trametinib | 1 | Drugs@FDA and literature search |
| Ursodeoxycholic acid | 0 | Drugs@FDA and literature search |
| Vandetanib | 1 | Drugs@FDA |
| Vemurafenib | 0 | Drugs@FDA and literature search |
FDA, US Food and Drug Administration; NIH, National Institutes of Health.
Note: Toxic: 1 (clinical incidence ≥ 0.1%), and nontoxic: 0 (clinical incidence <0.1%). https://dailymed.nlm.nih.gov/dailymed/
a
Domperidone was profiled by Drug Toxicity Signature Generation Center (DtoxS) and toxicity information was from http://www.hc-sc.gc.ca/dhp-mps/medeff/reviews-examens/domperidone-eng.php.