Table 1.

Demographic characteristics of the eight typical individuals implemented in the PBPK‐based simulation workflow and their corresponding system‐specific parameters values

Demographic values
Age	1 day	1 month	6 months	1 year	2 years	5 years	15 years	25 years
Bodyweight, kg	3.45	4.30	7.55	9.90	12.35	18.25	54.25	72.65
Height, cm	49.75	54.25	66.00	74.75	86.00	108.25	166.00	172.30
BSA, m2	0.22	0.26	0.38	0.46	0.55	0.74	1.60	1.86
System‐specific parameters
Qh, L/h	6.55	7.83	12.95	17.65	24.65	41.14	89.75	87.92
HSA, g/L	35.78	39.94	42.07	42.90	43.73	44.82	44.68	43.94
AAG, g/L	0.2678	0.5497	0.6774	0.7172	0.7512	0.7877	0.6711	0.6847
Hematocrit, %	51.93	38.14	35.11	35.78	36.79	38.29	40.01	40.74
Liver size, g	133	159	249	313	385	544	1351	1614
MPPGL	25.53	25.60	25.99	26.45	27.36	29.97	36.80	39.79
IO CYP1A2, %	24	35	118	150	164	161	126	100
IO CYP2A6, %	2.10−9	0.48	99	100	100	100	100	100
IO CYP2B6, %	15	19	34	47	62	83	99	100
IO CYP2C8, %	38	86	97	99	99	100	100	100
IO CYP2C9, %	40	74	87	90	92	100	100	100
IO CYP2C18–19, %	30	33	84	95	97	98	100	100
IO CYP2D6, %	6	47	84	91	95	98	100	100
IO CYP2E1, %	10	37	59	67	74	82	88	100
IO CYP3A4, %	11	13	48	78	96	104	106	100
IO UGT1A1, %	0.2	23	98	104	100	100	100	100
IO UGT1A4, %	74	74	74	75	77	81	97	100
IO UGT1A6, %	15	30	63	76	87	95	100	100
IO UGT1A9, %	9	12	34	52	71	90	100	100
IO UGT2B7, %	8	9	11	13	18	32	79	100
IO SULT1A1, %	100	100	100	100	100	100	100	100

AAG, alpha‐1 acid glycoprotein; BSA, body surface area; HSA, human serum albumin; MPPGL, milligram microsomal protein per gram of liver; IO, isoenzyme ontogeny expressed as percentage of adult microsomal intrinsic clearance; Qh, hepatic blood flow.