Table 3.
Classification of the C9ORF72 expansion carriers/noncarriers into diagnostic categories with the best performing MRI classification methods
| FTLD | AD | LBD | SMC | |
|---|---|---|---|---|
| VOL + VBM | ||||
| C9ORF72+ | 11 (65) | 1 (6) | 5 (29) | 0 |
| C9ORF72− | 19 (58) | 1 (3) | 11 (33) | 2 (6) |
| VOL | ||||
| C9ORF72+ | 8 (47) | 3 (18) | 5 (29) | 1 (6) |
| C9ORF72− | 14 (42) | 5 (15) | 9 (27) | 5 (15) |
| VBM | ||||
| C9ORF72+ | 12 (71) | 2 (12) | 3 (18) | 0 |
| C9ORF72− | 16 (48) | 4 (12) | 12 (36) | 1 (3) |
Values are shown as n (%). Suggestions for diagnostic categories as per quantification methods. The rows represent the methods used and the genetic subgroups of the C9ORF72 expansion carriers and noncarriers, while the columns represent the diagnostic suggestion. No statistically significant differences in differentiation accuracy between the genetic groups were found using only VOL and/or VBM. FTLD, frontotemporal lobar degeneration; AD, Alzheimer disease; LBD, Lewy body dementia; SMC, subjective memory complaints; VOL, volumetry; VBM, voxel-based morphometry.