Table 3.
CYP450 genes correlated with clinically relevant conjugating enzyme genes
| Gene 1 | Gene 2 | Correlation coefficienta | P‐value |
|---|---|---|---|
| Positive correlation | |||
| UGT1A1 | CYP3A7 | .96 | .003 |
| UGT1A5 | CYP1B1 | .86 | .024 |
| UGT1A9 | CYP1A1 | .86 | .024 |
| UGT2B4 | CYP2D6 | .86 | .024 |
| SULT1B1 | CYP1B1 | .82 | .034 |
| NAT2 | CYP2J2 | .82 | .034 |
| UGT1A1 | CYP2B6 | .79 | .048 |
| Negative correlation | |||
| GSTM1 | CYP4F2 | −.86 | .024 |
| UGT1A5 | CYP3A5 | −.79 | .048 |
| UGT1A5 | CYP2E1 | −.79 | .048 |
a
Spearman correlation as assumption of normal distribution could not be made. Data recovered via RNA‐seq. Only significant correlations reported (P < 0.05 by Spearman correlation).