Table 2.

Estimate of the population attributable risk and number of attributable cases in 2010 for AD and VaD

Risk factor	Prevalencea, %	ADa		VaD		Total number (in thousands) of attributable cases in 2010 for AD and VaD
		PAR, % (95% CI)	number (in thousands) of attributable cases in 2010 (95% CI)	PARb, % (95%CI)	number (in thousands) of attributable cases in 2010c (95% CI)
Diabetes mellitus	6.9	3.1	222	8.1	187	409
		(1.4–5.0)	(98–364)	(6.1–10.3)	(141–237)
Midlife hypertension	12.0	6.8	492	6.6	153	645
		(1.9–13.0)	(136–934)	(2.3–11.8)	(54–271)
Midlife obesity	7.2	4.1	299	2.3	54	353
		(2.4–6.2)	(172–448)	(0.1–5.1)	(3–118)
Physical inactivity	31.0	20.3%	1,461	15.9	367	1,828
		(5.6–35.6)	(401–2564)	(2.7–30.0)	(63–691)
Depression	18.5	10.7	774	26.2	605	1,379
		(7.2–14.5)	(520–1049)	(13.9–39.7)	(320–916)
Smoking	26.6	13.6	978	6.5	149	1,127
		(3.8–24.2)	(277–1,745)	(1.3–11.7)	(30–271)
Low educational attainment	26.6	13.6	978	31.8	733	1,711
		(8.5–18.6)	(614–1,342)	(24.0–39.5)	(555–910)
Combined		54.0	3,891	66.8	1,541	5,432
		(27.2–73.7)	(1,959–5,311)	(42.5–83.0)	(980–1,916)
Adjusted combined		31.4	3,033	37.8	873	3,906
		(15.3–46.0)	(1,472–4,332)	(21.2–52.5)	(488–1,211)

AD, Alzheimer disease; VaD, vascular dementia; PAR, population attributable risk.

^aEstimates from Norton et al. [3].

^bEstimated using the prevalence from Norton et al. [3] and risk ratio reported in Table 1.

^cEstimated multiplying PAR per number of prevalent cases of VaD in Europe (= 15.8 from Lobo et al. [2]; number of total cases of dementia from Brookmeyer et al. [9]).