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. 2018 Mar 27;8:5270. doi: 10.1038/s41598-018-22535-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Network analysis of integrated gene and metabolite changes in BeWo cells cultured in 25 mM glucose compared to 5 mM glucose. (A) 5632 genes and 41 metabolites that were differentially expressed (±1.3 FC) in BeWo cells following 48 h culture in 25 mM compared to 5 mM glucose were used to derive an interaction network inferred using MetScape (3.1.1) as visually represented here; dark blue circles represent gene changes seen in the BeWo dataset, light blue circles represent inferred gene interactions, dark red circles represent metabolite changes seen in the BeWo dataset, light red circles represent inferred metabolite interactions, grey lines represent protein-protein or protein-metabolite interactions. (B) Table of the metabolic pathways with the greatest number of gene and metabolite changes that were identified from the integrated gene and metabolite interactome network. Genes or metabolites shown in red were up-regulated, whereas those in green were down-regulated.