Skip to main content
. 2017 Nov 6;9(3):655–659. doi: 10.1039/c7sc03950f

Table 1. Optimization of the catalytic reductive aminocarbonylation of aryl iodide with nitroarene.

Inline graphic
Entry Variations from ‘standard conditions’ Yield a
1 None 100
2 L2 instead of L1 92
3 L3 instead of L1 91
4 L4 instead of L1 87
5 Mn (2 equiv.) instead of Zn 58
6 NMP instead of DMF 85
7 Fe(CO)5 (2 equiv.) instead of Co2(CO)8 26
8 Mo(CO)6 (2 equiv.) instead of Co2(CO)8 31
9 CO (1.4–2.4 bar) instead of Co2(CO)8 6–16
10 FeBr2 (10 mol%) instead of Ni(glyme)Cl2 10
11 CoCl2 (10 mol%) instead of Ni(glyme)Cl2 <5
12 CuBr2 (10 mol%) instead of Ni(glyme)Cl2 <5
13 MnCl2 (10 mol%) instead of Ni(glyme)Cl2 <5
14 No Ni(glyme)Cl2 <5
15 No L1 55

aCorrected GC yield using n-dodecane as an internal standard.