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. 2018 Mar 27;8:5259. doi: 10.1038/s41598-018-23324-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Schematic diagram of the alternative pathway of NF-kB (Reprinted from Lung Cancer, 89, 3, Dimitrakopoulos et al., 311–319, Variant of BCL3 gene is strongly associated with five-year survival of non-small-cell lung cancer patients, 2015, with permission from Elsevier). (B) Genomic positions of studied SNPs in NF-kB2 gene. (C) The study design outline. Abbreviations: BAFFR; tumor necrosis factor receptor superfamily member 13 C, CD40; CD40 molecule, TNF receptor superfamily member 5, LTβR; Lymphotoxin Beta Receptor (TNFR Superfamily, Member 3), RANK; Receptor Activator Of Nuclear Factor-Kappa B, NIK; NF-Kappa-Beta-Inducing Kinase, IKKα; IκB Kinase α, p100; nuclear factor NF-kappa-B p100 subunit, p52; nuclear factor NF-kappa-B p52 subunit, RELB; Transcription factor RelB, BCL3; B-Cell CLL/Lymphoma 3, FBXL15; F-Box and Leucine-Rich Repeat Protein 15, GBF1; Golgi Brefeldin A Resistant Guanine Nucleotide Exchange Factor 1, NF-kB2; nuclear factor-kappa B2, RPARP-AS1; RPARP antisense RNA 1.