Table 1.
ORs and 95% CIs for NSCLC in relation to genotypes of studied NF-kB2 SNPs.
| SNP | Counts | χ2 | Univariate analysisb | ||
|---|---|---|---|---|---|
| Genotype | Cases n (%) |
Controls n (%) |
P a | P | OR (95% CI) |
| Total | 268 | 279 | — | — | — |
| rs7897947 | 264 | 279 | — | — | — |
| ΤΤ | 145 (54,9) | 125 (44,8) | 0.052 | — | 1.000 |
| GT | 89 (33,7) | 120 (43,0) | 0.016 | 0.639 (0.444–0.920) | |
| GG | 30 (11,4) | 34 (12,2) | 0.326 | 0.761 (0.441–1.313) | |
| ΤΤ + GΤ vs GG |
234 (88,6) 30 (11,4) |
245 (87,8) 34 (12,2) |
0.766 | 1.082 (0.642–1.825) | |
| ΤΤ vs GT + GG |
145 (54,9) 119 (45,1) |
125 (44,8) 154 (55,2) |
0.019 | 1.501 (1.070–2.106) | |
| T allele | 379 (71.8) | 370 (66.3) | 0.051 | 0.052 | 1.292 (0.998–1.673) |
| G allele | 149 (28.2) | 188 (33.7) | 0.774 (0.598–1.002) | ||
| rs12769316 | 242 | 278 | — | — | — |
| AA | 20 (8.3) | 7 (2.5) | 0.012 | 1.000 | |
| AG | 62 (25.6) | 71 (25.5) | 0.005 | 0.280 (0.116–0.679) | |
| GG | 160 (66.1) | 200 (71.9) | 0.012 | 0.306 (0.121–0.771) | |
| AA + AG vs GG |
82 (33.9) 160 (66.1) |
78 (28.1) 200 (71.9) |
0.151 | 1.314 (0.905–1.909) | |
| AA vs AG + GG |
20 (8.3) 222 (91.7) |
7 (2.5) 271 (97.5) |
0.005 | 3.488 (1.448–8.399) | |
| A allele | 102 (21.1) | 85 (15.3) | 0.015 | 0.016 | 1.480 (1.077–2.033) |
| G allele | 382 (78.9) | 471 (84.7) | 0.676 (0.492–0.929) | ||
| rs11574852 | 261 | 278 | — | — | — |
| AA | 239 (91.6%) | 254 (91.4%) | 0.624 | — | 1.000 |
| AC | 22 (8.4%) | 23 (8.3%) | 0.999 | 0.984 (0.534–1.812) | |
| CC | 0 (0.0%) | 1 (0.4%) | — | — | |
| A allele | 0,9579 | 0,9585 | 0.821 | 0.821 | 1.070 (0.596–1.922) |
| C allele | 0,0421 | 0,0415 | 0.935 (0.520–1.679) | ||
aP derives from the χ2 test and refers to overall association of genotypes with NSCLC risk. bP, OR and 95% CI derived from logistic regression analysis. Abbreviations: CI, confidence interval; OR, odds ratios.