Table 2.
Univariate and multivariate Cox regression analysis for the LNN group.
| N (%) | Univariate | Multivariate | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MFS (25 events) | HFS (12 events) | OS (23 events) | MFS (25 events) | HFS (12 events) | OS (23 events) | |||||||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |||
| mRNA expression | miR-320 | 155 (100%) | 0.80(0.49–1.31) | 0.38 | 0.64(0.32–1.26) | 0.20 | 0.86(0.51–1.47) | 0.59 | ||||||
| miR-221 | 155 (100%) | 1.37(0.94–1.98) | 0.098 | 0.91(0.53–1.57) | 0.75 | 0.83(0.55–1.26) | 0.38 | |||||||
| miR-30b | 155 (100%) | 2.13(1.22–3.72) | 0.01 | 2.77(1.24–6.18) | 0.013 | 1.39(0.74–2.59) | 0.31 | |||||||
| miR-10b | 155 (100%) | 0.99(0.61–1.61) | 0.97 | 0.70(0.35–1.38) | 0.30 | 0.99(0.59–1.65) | 0.97 | |||||||
| miR-885–5p | 155 (100%) | 0.90(0.68–1.18) | 0.44 | 0.84(0.55–1.27) | 0.40 | 0.80(0.59–1.09) | 0.15 | |||||||
| let-7i | 155 (100%) | 0.69(0.45–1.07) | 0.10 | 0.32(0.17–0.60) | <0.001 | 0.94(0.54–1.30) | 0.43 | |||||||
| Gender | Female | 73 (47.1%) | 1 | 1 | 1 | |||||||||
| Male | 82 (52.9%) | 1.41(0.63–3.14) | 0.40 | 1.84(0.55–6.11) | 0.32 | 2.23(0.92–5.42) | 0.08 | |||||||
| Age | 155 (100%) | 1.004(0.96–1.05) | 0.88 | 1.01(0.94–1.09) | 0.75 | 1.08(1.02–1.14) | 0.01 | |||||||
| Tumour stage | Stage I | 57 (36.8%) | 1 | 1 | 1 | |||||||||
| Stage II | 98 (63.2%) | 1.51(0.63–3.61) | 0.36 | 1.17(0.35–3.90) | 0.79 | 1.07(0.45–2.53) | 0.88 | |||||||
| T status | T2 | 57 (36.8%) | 1 | 1 | 1 | |||||||||
| T3 | 98 (63.2%) | 1.51(0.63–3.61) | 0.36 | 1.17(0.35–3.90) | 0.79 | 1.07(0.45–2.53) | 0.88 | |||||||
| Nodal status | N0 | 127 (81.9%) | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| N0 < 10 nodes | 28 (18.1%) | 1.20(0.45–3.20) | 0.72 | 3.42(1.08–10.76) | 0.04 | 1.51(0.59–3.86) | 0.39 | 1.08(0.40–2.88) | 0.88 | 2.91(0.92–9.19) | 0.07 | 1.44(0.55–3.75) | 0.45 | |
| Tumour grade | Good | 13 (8.4%) | 1 | 1 | 1 | |||||||||
| Moderate | 130 (83.9%) | 1.01(0.24–4.31) | 0.99 | 0.91(0.12–7.19) | 0.93 | 1.98(0.27–14.80) | 0.51 | |||||||
| Poor | 9 (5.8%) | 2.12(0.35–12.69) | 0.41 | 2.85(0.26–31.39) | 0.39 | 4.47(0.46–43.17) | 0.20 | |||||||
| Otherb | 3 (1.9%) | — | — | — | ||||||||||
| Location | Right | 79 (51.0%) | 1 | 1 | 1 | |||||||||
| Left | 76 (49.0%) | 1.91(0.84–4.32) | 0.12 | 1.08(0.35–3.33) | 0.90 | 0.60(0.25–1.40) | 0.24 | |||||||
| MSI-status a | MSI | 34 (22.1%) | 1 | 1 | 1 | |||||||||
| MSS | 120 (77.9%) | 3.46(0.82–14.70) | 0.09 | 30.43(0.1–9228.65) | 0.24 | 0.48(0.21–1.11) | 0.09 | |||||||
| Modified signature | low risk | 79 (51.0%) | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| high risk | 76 (49.0%) | 2.73(1.14–6.55) | 0.02 | 11.19(1.45–86.69) | 0.02 | 1.31(0.57–2.99) | 0.52 | 2.72(1.13–6.53) | 0.03 | 10.30(1.33–79.992) | 0.03 | 1.24(0.53–2.87) | 0.62 | |
aOne missing value; bthere were no events in this subgroup.