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. Author manuscript; available in PMC: 2019 Feb 9.
Published in final edited form as: ACS Infect Dis. 2017 Dec 13;4(2):118–122. doi: 10.1021/acsinfecdis.7b00178

Table 2.

Summary of MIC (S. mutans, S. sanguinis, and S. gordonii) and MBC (S. mutans) Values for Analogsa

Analog MIC
S. mutans 		MIC
S. sanguinis 		MIC
S. gordonii 		MBC
S. mutans
A 1 250 125 125 -
2 32 32 32 63
3 >250 >250 >250 -
4 >250 >250 >250 -
5 >250 >250 >250 -
6 >250 >250 >250 -
7 32 32 16 32
8 >250 125 125 -
9 >250 >250 >250 -
10 >250 250 250 -
11 >250 >250 >250 -
B 1 >250 >250 >250 -
2 >250 >250 >250 -
3 63 63 63 -
4 125 125 125 -
5 8 4 16 125
6 >250 >250 >250 -
7 125 63 125 -
8 16 8 16 32
9 32 32 32 32
10 32 8 8 32
11 16 8 16 63
12 >250 250 250 -
13 >250 >250 >250 -
14 63 16 32 -
C 1 >250 125 125 -
2 2 2.5 1.25 4
a

MIC and MBC values were completed in biological triplicate. MBC assays were completed for analogs with MIC values <32 µM.