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Sequence comparison of CRF and sauvagine (Svg) analogs. A dash marks an identical amino acid residue. The ARAE motif of h/rCRF and the aligned corresponding stretches of residues of other CRF-like peptides are boxed. The site of the Glu/Ala switch is underlayed in gray. The bracket between Glu30 and Lys33 of the astressin (Ast) analogs depicts the lactam bridge connecting the side chains of Glu30 and Lys33. B, norleucine; Z, pyroglutamic acid; f, d-phenylalanine; ■, C-terminal amide.
