Table 3.
Multivariate Logistic Regressiona of Guideline-Concordant Care According to Comorbidity, Age, and Race in Individuals with Breast Cancer (N = 6,208b)
| Comorbidity Group (Model) | Model 1 (Includes Each 26 Separate ACE-27 Comorbidity Categories in the Model) | Model 2 (Includes 12 Collapsed ACE-27 Categories in the Model) | Model 3 (Includes 4 Levels of Comorbidity in the Model) | |
|---|---|---|---|---|
|
|
|
|||
| 1 (1) | 2 (2) | Odds Ratio (95% Confidence Interval) | ||
| Myocardial infarction | 0.94 (0.64–1.37) | |||
|
| ||||
| Coronary artery disease | 0.97 (0.74–1.28) | |||
|
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| Congestive heart failure | 0.74 (0.52–1.07) | |||
|
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| Arrhythmia | 0.90 (0.64–1.26) | |||
|
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| Hypertension | 1.15 (1.01–1.30)c | |||
|
| ||||
| Venous disease | 1.13 (0.67–1.92) | |||
|
| ||||
| Peripheral arterial disease | Cardiovascular | 0.67 (0.36–1.22) | 1.13 (1.00–1.28) | |
|
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| Respiratory disease | Respiratory | 1.18 (0.93–1.51) | 1.14 (0.89–1.44) | |
|
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| Hepatic disease | 0.62 (0.33–1.19) | |||
|
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| Stomach or intestinal disease | 1.01 (0.68–1.51) | |||
|
| ||||
| Pancreatic disease | Gastrointestinal | 0.88 (0.63–1.23) | ||
|
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| Renal system disease | Renal system disease | 0.64 (0.36–1.12) | 0.57 (0.33–0.99)c | |
|
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| Diabetes mellitus | Diabetes mellitus | 0.91 (0.76–1.08) | 0.88 (0.75–1.06) | |
|
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| Stroke or cerebrovascular accident | 0.78 (0.55–1.11) | |||
|
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| Dementia | 0.45 (0.24–0.83)c | |||
|
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| Paralysis | 0.88 (0.14–5.66) | |||
|
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| Neuromuscular disease | Nervous system | 0.62 (0.34–1.15) | 0.62 (0.47–0.82)c | |
|
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| Psychiatric disease | Psychiatric disease | 1.28 (1.00–1.63) | 1.27 (0.99–1.62) | |
|
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| Rheumatological disease | Rheumatological disease | 0.79 (0.54–1.15) | 0.80 (0.55–1.17) | |
|
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| AIDS | AIDS | 0.25 (0.04–1.52) | 0.25 (0.04–1.53) | |
|
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| Solid tumor | 0.54 (0.27–1.09) | |||
|
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| Leukemia | ||||
|
| ||||
| Lymphoma | Cancer | 0.623 (0.328–1.183) | ||
|
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| Alcohol abuse | 1.006 (0.487–2.077) | |||
|
| ||||
| Illicit drugs | Substance abuse | 0.827 (0.296–2.310) | 1.021 (0.547–1.904) | |
|
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| Obesity | Obesity | 1.108 (0.900–1.363) | 1.108 (0.901–1.363) | |
|
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| Comorbidity index (vs none) | ||||
|
| ||||
| Mild | 1.124 (0.990–1.277) | |||
|
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| Moderate | 1.117 (0.919–1.359) | |||
|
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| Severe | 0.673 (0.507–0.893)c | |||
|
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| Age (vs <50) | ||||
|
| ||||
| 50–64 | 0.653 (0.563–0.757)c | 0.657 (0.566–0.762)c | 0.652 (0.563–0.756)c | |
|
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| 65–74 | 0.394 (0.325–0.478)c | 0.395 (0.326–0.480)‡ | 0.385 (0.318–0.465)c | |
|
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| ≥75 | 0.135 (0.109–0.167)c | 0.131 (0.106–0.162)c | 0.126 (0.102–0.155)c | |
|
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| Race (vs white) | ||||
|
| ||||
| Black | 0.872 (0.763–0.996)c | 0.878 (0.769–1.002) | 0.873 (0.767–0.993)c | |
|
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| Hispanic | 0.924 (0.743–1.149) | 0.932 (0.749–1.159) | 0.907 (0.730–1.126) | |
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| Other | 0.944 (0.741–1.203) | 0.949 (0.745–1.208) | 0.933 (0.733–1.186) | |
a
Controlling for stage and source of payment; pancreatic disease, lymphoma, and leukemia excluded from Model 1 because of too few observations (<5).
b
Observations excluded (n = 231) for missing payer or race, also omitted metastatic, missing stage, if both PR and ER receptors missing, and if tumor size missing and nodes less than N1.
c
Statistically significant, three levels of comorbidity and none, chi-square, P < .05.
ACE = Adult Comorbidity Evaluation; AIDS = acquired immunodeficiency syndrome.