Table 5.
Ordinal logistic regression describing the association between alcohol consumption and aortic calcification score for the ERA-JUMP Study, 2002–2006.
| Alcohol categories | Non-drinkers | Light drinkers | Moderate drinkers | Heavy drinkers | – |
|---|---|---|---|---|---|
| All Participants (n = 1006) | |||||
|
| |||||
| n (%) | 258 (25.6) | 355 (35.3) | 236 (23.5) | 157 (15.6) | – |
|
| |||||
| Mean AoCaS | 81.2 | 107.7 | 112.5 | 283.7 | – |
|
| |||||
| OR | OR (95% CI) | OR (95% CI) | OR (95% CI) | p-trenda | |
|
| |||||
| Unadjusted | 1.00 | 0.92 (0.68, 1.23) | 0.68 (0.49, 0.94) | 1.05 (0.73, 1.52) | 0.15/0.30 |
| Model I | 1.00 | 1.02 (0.74, 1.39) | 0.79 (0.56, 1.12) | 1.67 (1.13, 2.47) | 0.19/0.31 |
| Model II | 1.00 | 1.10 (0.79, 1.52) | 0.86 (0.60, 1.23) | 1.67 (1.11, 2.52) | 0.48/0.32 |
| Model III | 1.00 | 1.07 (0.77, 1.50) | 0.83 (0.58, 1.21) | 1.54 (0.99, 2.40) | 0.47/0.55 |
|
| |||||
| Race/ethnicity stratified analyses | |||||
|
| |||||
| US White (n = 301) | |||||
|
| |||||
| n (%) | 57 (18.9) | 162 (53.8) | 71 (23.6) | 11 (3.7) | – |
|
| |||||
| Mean AoCaS | 66.7 | 105.7 | 90.7 | 381.0 | – |
|
| |||||
| OR | OR (95% CI) | OR (95% CI) | OR (95% CI) | p-trenda | |
|
| |||||
| Model II | 1.00 | 1.26 (0.69, 2.31) | 1.10 (0.55, 2.23) | 1.30 (0.35, 4.84) | 0.65/0.85 |
| Model III | 1.00 | 1.21 (0.65, 2.25) | 1.10 (0.53, 2.29) | 1.62 (0.42, 6.35) | 0.87/0.61 |
|
| |||||
| Japanese in Japan (n = 310) | |||||
|
| |||||
| n (%) | 53 (17.1) | 82 (26.5) | 81 (26.1) | 94 (30.3) | – |
|
| |||||
| Mean AoCaS | 121.0 | 76.5 | 67.7 | 251.3 | |
|
| |||||
| OR | OR (95% CI) | OR (95% CI) | OR (95% CI) | p-trenda | |
|
| |||||
| Model II | 1.00 | 1.02 (0.46, 2.25) | 0.96 (0.44, 2.12) | 1.68 (0.79, 3.55) | 0.69/0.39 |
| Model III | 1.00 | 0.89 (0.39, 2.01) | 1.00 (0.44, 2.27) | 1.40 (0.62, 3.14) | 0.60/0.43 |
|
| |||||
| Japanese American (n = 292) | |||||
|
| |||||
| n (%) | 113 (38.7) | 75 (25.7) | 59 (20.2) | 45 (15.4) | |
|
| |||||
| Mean AoCaS | 82.1 | 157.8 | 224.9 | 232.5 | – |
|
| |||||
| OR | OR (95% CI) | OR (95% CI) | OR (95% CI) | p-trenda | |
|
| |||||
| Model II | 1.00 | 1.16 (0.66, 2.05) | 0.78 (0.42, 1.44) | 1.47 (0.75, 2.87) | 0.83/0.97 |
| Model III | 1.00 | 1.21 (0.68, 2.17) | 0.81 (0.43, 1.53) | 1.38 (0.66, 2.91) | 0.96/0.88 |
OR, odds ratio; CI, confidence interval; AoCaS, aortic calcification score.
Model I: alcohol consumption, age, race, years of education.
Model II: Model I + pack-years of smoking, BMI, diabetes, anti-lipid medication, job physical activity, meat intake, LDL-C, and CRP.
Model III: Model II + HDL-C, triglycerides, hypertension, and fibrinogen.
a
p-trend shows p-values for linear and quadratic trends across the alcohol consumption categories calculated using contrast.