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. 2018 Mar 27;8:5277. doi: 10.1038/s41598-018-22870-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cell lysis upon rejuvenation. Trends of RBCs lysis observed after revitalization performed, respectively, at day 2 (panel a); day 8 (b) and day 11 (c). In the three panels, the 0 was set at the time of rejuvenation and the plots report the lysis observed in the following days. In RBCs rejuvenated after 8 (b) and 11 (c) days of aging, some differences emerge: the microgravity-exposed cells always behave as the more stressed samples i.e. they show higher lysis rate than in the static.