Table 4.
Minimum Inhibitory Concentrations (MICs) in μg/mL of Compounds against Two Strains of S. aureus and Three Strains of E. colia
| Gram-positive | Gram-negative | ||||
|---|---|---|---|---|---|
|
| |||||
| Compound | S. aureus | E. coli | |||
| ATCC 29213 | ATCC 700699 | ATCC 25922 | ACH-0095 | PBR322 | |
| Tetracycline (2) | 1 | >64 | 1 | >64 | >64 |
| 148 | 1 | 2 | 4 | 16 | 16 |
| 149 | >64 | >64 | >64 | ND | ND |
| 150 | 8 | >64 | 2 | >64 | 64 |
| 151 | 16 | 64 | 32 | ND | ND |
| 152 | 1 | 1 | >64 | >64 | 64 |
a
In each category, the first strain listed is a susceptible QC strain; the second strain is a tetracycline-resistant clinical isolate. pBR322 is an engineered laboratory strain carrying a plasmid marker for tetracycline resistance. ND = not determined.