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. Author manuscript; available in PMC: 2018 Oct 11.
Published in final edited form as: Chem Rev. 2017 Sep 27;117(19):12415–12474. doi: 10.1021/acs.chemrev.7b00283

Table 5.

Evaluation of Viridicatumtoxin B and Related Analogs against a Panel of Gram-Positive and −Negative Bacteriaa
VRE MRSA Gram-(−)
E. faecalis
S613		 E. faecium
105		 S. aureus
371		 A. baumannii
AB210
minocycline (132) 8 8 1 4
tigecycline (133) 0.5 0.25 2 0.5
(+)-158 2 2 4 64
(−)-158 4 4 8 64
(+)-175 8 8 8 64
(−)-175 16 16 32 64
(+)-176 16 16 8 64
(−)-176 8 16 64 64
(−)-177 128 64 128 64
(+)-177 1 2 64 64
(−)-178 4 8 8 64
(+)-178 2 8 8 64
(+)-179 0.5 2 2 64
(−)-179 1 1 2 64
(−)-180 1 0.5 2 64
(+)-180 1 1 2 64
a

MICs in μg/mL. Minocycline and tigecycline serve as positive controls. Analogs with enhanced activity against both VRE and MRSA relative to the natural product are highlighted in green.